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Rimonabant will be made available to overweight or obese patients who cannot take, or who have had no success with, two other drugs, orlistat and sibutramine. It comes after concerns about rimonabant's side effects, including suicidal thoughts and depression. The Medicines and Healthcare Products Regulatory Agency said last month that it had received 720 reports of adverse drug reactions - totalling 2,123 individual reactions - in the UK since the drug was launched in 2006. But the National Institute for Clinical Excellence said: "Being overweight or obese can lead to a range of serious health problems, including heart disease, type-2 diabetes, osteoarthritis and some cancers." Copyright c 2008 Independent Newspapers UK Limited. All rights owned or operated by The Independent.
Abstract Introduction: Obesity and overweight affect over 1 billion people worldwide and are leading causes of morbidity and mortality. Clinical features of obesity converge with those of the metabolic syndrome and type 2 diabetes, greatly increasing the risk of long-term adverse outcomes. Aims: To review the evidence on rimonabant, a novel CB1 receptor antagonist, for the treatment of obese and overweight patients. Related Results Lancet, BMJ studies sound concern over anti-obesity drug rimonabantRimonabant improves cardiovascular risk profileRimonabant improves cardiovascular risk profileNew drug application for rimonabant pulledRimonabant enhanced weight loss success, improved lipids Evidence review: There is clear evidence that rimonabant 20 mg/day in conjunction with a hypocaloric diet causes a mean weight loss of 4.
