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Effective weight loss with Rimonabant

Although the committee's recommendations are not binding, but the FDA generally follows the advice of its advisory panels. The Advisory Committee indicated during the meeting that he is prepared for the issue of psychiatric medication side effects after Sanofi completes the 17000-patient? Rimonabant Comprehensive Evaluation Study of Cardiovascular endpoints and results (CRESCENDO) in 2010, that study will have 5-year follow-up data on patients and. Approximately 8000 patients were recruited and the CRESCENDO study to date, Mr. Cluzel said. The announcement that the drawing of its new drug application for rimonabant, Sanofi not say whether it will wait until these results are in, but the company has acknowledged that the duration of treatment was a major focus of the panel.

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Of the patients and 20 mg / day rimonabant, 39% lost more than 10% of their initial body weight, just as 15% of those on 5 mg / day and 12% of those on placebo. It is known that a 10% loss of body weight in combination with an 8 - to 10-cm decrease in waist circumference translates into a 25% -30% reduction in metabolic harmful visceral fat. A significantly improved insulin response to an oral glucose tolerance test was also noted by patients and 20 mg / day rimonabant. Previous studies have shown that weight loss of rimonabant is mainly due to reduced food craving for two groups: sweets and fats, Dr. Van Gaal said. The only adverse events more common in patients and rimonabant than placebo patients were mild and transient nausea and diarrhea.

It would have been much more convincing to have analyzed actual data on the vast majority of this randomized, "Dr Simons - Morton and her associates said. In addition, the drug of the potential adverse effects should be examined in more detail . Dr Pi-Sunyer and associates said rimonabant was "generally well tolerated, with adverse effects are usually mild and moderate." by Mary Ann MOON Contributing Writer COPYRIGHT 2006 International Medical News Group COPYRIGHT 2008 Gale, Cengage Learning.