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A new class of weight-loss drugs that suppresses appetite by blocking cannabinoid receptors in the brain should be used with caution in children, U. S.scientists report. In research with mice, they found this class of drugs also suppresses the adaptive rewiring of the brain necessary for neural development in young animals. The findings are in the May 8 issue of Neuron. One such drug is rimonabant (Acomplia), which was developed by Sanofi-Aventis and is awaiting approval by the U. S. Food and Drug Administration. Other pharmaceutical companies are developing similar drugs. Related Results Cheyenne, Wyo.-area doctors skeptical of 'super bill' for weight loss, smoking.
Two-thirds of the patients completed the 1-year trial. The three groups were similar at baseline, with a mean age of 56 years, hemoglobin [A.sub. 1c] of 7. 5%, BMI of 34, and waist circumference of 110 cm. About 60% had hypertension, 55% had dyslipidemia, and 80% met criteria for metabolic syndrome. About two-thirds were taking metformin; one-third were taking sulfonylureas. They stayed on those drugs during the study. In the intent-to-treat analysis of the original 1,045 patients with the last observation carried forward, those randomized to 20 mg/day of rimonabant lost a mean of 5. 3 kg, compared with 1. 4 kg in the placebo group, a highly significant difference.
