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MADRID -- Rimonabant, the novel cannabinoid type 1 receptor-blocking drug that has been gaining considerable attention for its ability to induce weight loss, improve glucose metabolism, raise HDL cholesterol and lower triglycerides, also appears to lead to small but meaningful reductions in blood pressure in hypertensive obese patients. That finding comes from a new analysis of pooled data from the four major international rimonabant trials involving over 6,600 patients. Among patients with elevated blood pressure at baseline (greater than 143/89 mm Hg for nondiabetics, and greater than 130/85 mm Hg for diabetics), the use of rimonabant at a dose of 20 mg/day was associated with a mean systolic pressure reduction of 7. 5 mm Hg and a mean diastolic reduction of 5.
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